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Journal of Obstrectic Anaesthesia and Critical Care
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Year : 2022  |  Volume : 12  |  Issue : 2  |  Page : 105-115

Rotational thromboelastometry reference range during pregnancy, labor and postpartum period: A systematic review with meta-analysis

1 Federal State Budgetary Educational Institution of Higher Education Tver State Medical University of the Ministry of Health of Russia. St. Sovetskaya, H. 4; E.M. Bakunina Regional Clinical Perinatal Centre. Peterburgskoe Highway, H. 155/3, Tver, Russia
2 M.F. Vladimirskiy Moscow Regional Research Clinical Institute, St. Shhepkina, H. 61/2, Moscow, Russia
3 Ural State Medical University. St. Repina, H. 3, Yekaterinburg, Russia
4 Institute of Postgraduate Education of the Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenetsky. St. Partizana Zheleznyak, H. 1; “Krasnoyarsk Regional Clinical Center for the Protection of Mothers and Children”, St. Academician Kirensk., H. 2A, Krasnoyarsk, Russia
5 Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen; Medical Department, Tem Innovations, Munich, Germany
6 Shaare Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel
7 Petrozavodsk State University, Institute of High Biomedical Technologies, Laboratory of Clinical Epidemiology. Av. Lenin, H. 33, Petrozavodsk, Resp. Karelia, Russia

Correspondence Address:
Dr. Alexander M Ronenson
Tver Region, Tver, St. Respublikanskaya 9-20, Postal Index 170024
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JOACC.JOACC_21_22

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Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) have become increasingly popular for urgent assessment of the hemostasis system. Accordingly, TEG and ROTEM algorithms and their corresponding cut-off values are not interchangeable. ROTEM provides fast results (including validated early clot firmness parameters [A5 and A10]), that are easy to use, and the graphical display of the results is easy to interpret. ROTEM manufacturer, Tem Innovations GmbH (Munich, Germany), mentions in the user manual that the manufacturer has not set any strict reference values for INTEM, EXTEM, FIBTEM, APTEM, and NATEM in any patient population (including pregnant women) and that these values are highly variable in healthy subjects. To date, no systematic review assessing ROTEM parameters in pregnant, parturient, and postpartum women is available. With the increasing usage of ROTEM, we conducted this systematic review and meta-analysis to determine the reference values of ROTEM parameters in pregnant, parturient, and postpartum women compared with non-pregnant population.

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