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Journal of Obstrectic Anaesthesia and Critical Care
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Year : 2020  |  Volume : 10  |  Issue : 1  |  Page : 42-44

Acute fatty liver of pregnancy and disseminated intravascular coagulation: A case report

Department of Anesthesiology, UMass-Baystate Medical School, Springfield, MA, USA

Correspondence Address:
Dr. Michael R Chalifoux
Department of Anesthesiology, UMass-Baystate Medical School, 759 Chestnut Street, Springfield, MA, 01199
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/joacc.JOACC_8_20

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28-year-old G1P0 at 33 weeks gestation presented with abdominal pain, elevated blood pressures and worsening edema. Laboratory workup revealed abnormal transaminases and hypofibrinogenemia. Diagnoses of disseminated intravascular coagulation (DIC) and acute fatty liver of pregnancy (AFLP) were made and out of concern for placental abruption, an emergency cesarean section was planned. Preoperatively, cryoprecipitate and fresh frozen plasma (FFP) were administered. Cesarean delivery was performed under general anesthesia. Postoperatively, her course was complicated by ongoing metabolic derangements and acute liver failure. She was transferred to a liver transplant facility and remained hospitalized for several months with gradual clinical improvement.

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