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Journal of Obstrectic Anaesthesia and Critical Care
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Year : 2014  |  Volume : 4  |  Issue : 1  |  Page : 12-17

Intrathecal isobaric ropivacaine-fentanyl versus intrathecal isobaric bupivacaine-fentanyl for labor analgesia: A controlled comparative double-blinded study

Department of Anaesthesia, Dr. Lakhumal Hiranand Hiranadani Hospital, Powai, Mumbai, Maharashtra, India

Correspondence Address:
Meenoti Pramod Potdar
Department of Anaesthesia, Dr. Lakhumal Hiranand Hiranadani Hospital, Hillside Avenue, Hiranandani Gardens, Powai, Mumbai - 400 076, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2249-4472.132814

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Context: Neuraxial analgesia and walking epidural is the popular method of practicing labor analgesia. The combination of local anesthetic and opioid is advantageous as it prolongs the duration of labor analgesia. Ropivacaine is the newer local anesthetic agent having lesser motor effects and toxic effects hence would be preferred for labor analgesia. Aims: The primary objective of the study was to assess the duration of analgesia of the intrathecal drug. The secondary objective was the assessment of onset, fixation of analgesia, motor weakness, ambulation, sedation, incidence of side-effects, maternal, and neonatal outcomes. Settings and Design: This is prospective, randomized, controlled, double-blinded, study of 120 patients consenting for labor analgesia. Subjects and Methods: A total of 120 primiparas with a singleton pregnancy in active labor who were given combined spinal epidural (CSE) were included in the study. These patients were randomly allocated to three groups of 40 each and received CSE. Group F-received 25 μcg fentanyl intrathecally. Group BF-received 25 μcg fentanyl with 2.5 mg isobaric bupivacaine intrathecally. Group RF-received 25 μcg fentanyl with 2.5 mg isobaric ropivacaine intrathecally. Statistical Analysis Used: Correlations among different measurements were assessed using Pearson's correlation coefficients, P <0.05 was considered to be statistically significant. Results: The three groups show comparable demographic data and obstetric parameters. The duration of spinal analgesia was significantly greater with Group RF 106.63 ± 17.99 min and Group BF 111.75 ± 23.58 min than the control Group F which was 60 ± 10.39 min with P = 0.001, but were comparable for Group BF and RF. The secondary outcome was comparable in all the three groups. Conclusions: The addition of bupivacaine or ropivacaine to fentanyl intrathecally increased duration and quality of analgesia, did not affect ambulation and bearing down. The incidence of side-effects, maternal and neonatal outcomes and maternal satisfaction were comparable in all groups. Hence, the effect of both the local anesthetics with fentanyl intrathecally has similar effects, and there was no added advantage of ropivacaine over bupivacaine.

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